Predicted to be a structural constituent of ribosome. Predicted to act upstream of or within mitochondrial translation. Located in mitochondrion. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and immune system. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 50. Orthologous to human MRPS25 (mitochondrial ribosomal protein S25).
MGI Description
PHENOTYPE: Mice homozygous for a knock-out allele exhibit embryonic growth retardation, failure of primitive streak formation, disorganized extraembryonic tissue, and complete embryonic lethality by E9.5. [provided by MGI curators]