Gene

Mtor

Species
Mus musculus
Symbol
Mtor
Name
mechanistic target of rapamycin kinase
Synonyms
  • 2610315D21Rik
  • AI327068
Biotype
protein coding gene
Automated Description
Enables protein serine/threonine kinase activity and ribosome binding activity. Involved in several processes, including 'de novo' pyrimidine nucleobase biosynthetic process; T-helper 1 cell lineage commitment; and TORC2 signaling. Acts upstream of or within several processes, including heart development; positive regulation of cellular component biogenesis; and protein phosphorylation. Located in cytosol; dendrite; and nucleus. Part of TORC1 complex and TORC2 complex. Colocalizes with PML body. Is expressed in several structures, including central nervous system; early conceptus; eye; oocyte; and respiratory system. Human ortholog(s) of this gene implicated in autosomal dominant polycystic kidney disease; kidney angiomyolipoma; lung disease (multiple); prostate cancer; and type 2 diabetes mellitus. Orthologous to human MTOR (mechanistic target of rapamycin kinase).
MGI Description
PHENOTYPE: Mice homozygous for targeted, gene trap and ENU-induced null alleles exhibit embryonic lethality by E12.5 with abnormal embryogenesis. Mice homozygous for the ENU mutation further exhibit abnormal brain development. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11139
No data available
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCm39
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            148.54M148.55M148.56M148.57M148.58M148.59M148.60M148.61M148.62M148.63M148.64M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Mtor molecule type
            Interactor gene
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              Genetic Interactions

              Mtor role
              Mtor genetic perturbation
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