Gene

Scube2

Species
Mus musculus
Symbol
Scube2
Name
signal peptide, CUB domain, EGF-like 2
Synonyms
  • 4932442O19Rik
  • Cegf1
Biotype
protein coding gene
Automated Description
Enables hedgehog family protein binding activity. Acts upstream of or within several processes, including chondrocyte differentiation involved in endochondral bone morphogenesis; positive regulation of chondrocyte proliferation; and positive regulation of osteoblast differentiation. Located in extracellular space. Is expressed in several structures, including cardiovascular system; central nervous system; neural ectoderm; sensory organ; and skeleton. Orthologous to human SCUBE2 (signal peptide, CUB domain and EGF like domain containing 2).
MGI Description
PHENOTYPE: Mice homozygous for a null mutation are smaller than controls. Mice also exhibit defective endochondral bone formation and impaired Ihh-mediated chondrocyte differentiation. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24046
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensSCUBE29 of 10YesYes  
Rattus norvegicusScube29 of 9YesYes   
Xenopus tropicalisscube24 of 9YesYes   
Danio rerioscube29 of 10YesYes  
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
Scube31104668544 of 9 
Scube1296870574 of 9 

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
abnormal bone ossification
abnormal chondrocyte differentiation
abnormal endochondral bone ossification
abnormal long bone epiphyseal plate proliferative zone
abnormal long bone hypertrophic chondrocyte zone
abnormal skeleton development
abnormal trabecular bone morphology
decreased body height
decreased body length
decreased body size
Showing 1 - 10 of 20 rows
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

No mapped variant information available
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
Scube2tm1.1Rbyaallele
Yes
Scube2em1Gpt
  • Scube2em1Cflox
allele
Scube2tm1Rbya
  • Scube2Flox
allele
Yes
NC_000073.7:g.109402491T>Avariant
SNP
  • intron variant
NC_000073.7:g.109402691A>Gvariant
SNP
  • intron variant
NC_000073.7:g.109403122C>Tvariant
SNP
  • intron variant
NC_000073.7:g.109403129G>Avariant
SNP
  • intron variant
NC_000073.7:g.109403455C>Tvariant
SNP
  • intron variant
NC_000073.7:g.109407483C>Tvariant
SNP
  • intron variant
NC_000073.7:g.109407568C>Tvariant
SNP
  • intron variant
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Transgenic Alleles

No data available

Models

Model name
Experimental condition
Associated Human Diseases
Associated Phenotypes
Modifier
Source
Scube2tm1.1Rbya/Scube2tm1.1Rbya [background:] B6.129-Scube2tm1.1Rbya
  • abnormal bone ossification
  • abnormal chondrocyte differentiation
MGI
Scube2tm1Rbya/Scube2tm1Rbya [background:] involves: 129S1/Sv * 129X1/SvJ
  • abnormal skeleton development
MGI
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Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
109.40M109.41M109.42M109.43M109.44M109.45M109.46M

Sequence Details

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Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

No data available

Genetic Interactions

No data available