Gene

Arpc1a

Species
Mus musculus
Symbol
Arpc1a
Name
actin related protein 2/3 complex, subunit 1A
Synonyms
  • 0610010H08Rik
  • 1110030K07Rik
Biotype
protein coding gene
Automated Description
Predicted to enable actin filament binding activity. Predicted to be involved in Arp2/3 complex-mediated actin nucleation. Located in muscle cell projection membrane. Is active in glutamatergic synapse. Is expressed in central nervous system and retina. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human ARPC1A (actin related protein 2/3 complex subunit 1A).
MGI Description
Not Available
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10709
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
Arpc1b137384687 of 9 

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Transgenic Alleles

No data available

Models

Model name
Experimental condition
Associated Human Diseases
Associated Phenotypes
Modifier
Source
Arpc1aem1(IMPC)J/Arpc1a+ [background:] C57BL/6NJ-Arpc1aem1(IMPC)J/Mmjax
  • decreased bone mineral content
MGI
Arpc1aem1(IMPC)J/Arpc1aem1(IMPC)J [background:] C57BL/6NJ-Arpc1aem1(IMPC)J/Mmjax
  • abnormal neural tube closure
  • abnormal pharyngeal arch morphology
MGI
Showing 1 - 2 of 2 rows
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Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
145.022M145.024M145.026M145.028M145.030M145.032M145.034M145.036M145.038M145.040M145.042M145.044M

Sequence Details

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Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

22 interactor genes based on 22 annotations
Arpc1a molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
Aarsd1Mus musculus
protein
  • biochemical
PMID:32325033
protein
Actr2Mus musculus
protein
  • biochemical
PMID:32325033
protein
Actr3Mus musculus
protein
  • biochemical
PMID:32325033
protein
Agap2Mus musculus
protein
  • affinity chromatography technology
PMID:28706196
protein
Agfg1Mus musculus
protein
  • biochemical
PMID:32325033
protein
Arpc2Mus musculus
protein
  • biochemical
PMID:32325033
protein
Arpc3Mus musculus
protein
  • biochemical
PMID:32325033
protein
Arpc4Mus musculus
protein
  • biochemical
PMID:32325033
protein
Arpc5Mus musculus
protein
  • biochemical
PMID:32325033
protein
Arpc5lMus musculus
protein
  • biochemical
PMID:32325033
Showing 1 - 10 of 22 rows
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Genetic Interactions

No data available