Version: 8.0.0
Date: Tue Jan 28 2025
Rybp
Mus musculusMGI:1929059
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Rybp

Species
Mus musculus
Symbol
Rybp
Name
RING1 and YY1 binding protein
Synonyms
  • 2410018J24Rik
  • DEDAF
Biotype
protein coding gene
Automated Description
Enables DNA binding activity and transcription corepressor activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleoplasm. Is expressed in several structures, including central nervous system; early embryo; extraembryonic component; genitourinary system; and hemolymphoid system gland. Orthologous to human RYBP (RING1 and YY1 binding protein).
MGI Description
PHENOTYPE: Homozygous null mice initiate implantation but fail to complete decidualization and display early embryonic lethality. A subset of heterozygotes show forebrain overgrowth, delayed neural tube closure, exencephaly, failed optic fissure closure, malformed lenses, and retinal/optic nerve colobomas. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12920
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          GRCm39
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Rybp molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            Rybp role
            Rybp genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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