Gene

Ap3m2

Species
Mus musculus
Symbol
Ap3m2
Name
adaptor-related protein complex 3, mu 2 subunit
Synonyms
  • 5830445E16Rik
  • AP-3B
Biotype
protein coding gene
Automated Description
Involved in anterograde synaptic vesicle transport and synaptic vesicle endocytosis. Is active in GABA-ergic synapse and glutamatergic synapse. Is expressed in central nervous system; ganglia; and sensory organ. Orthologous to human AP3M2 (adaptor related protein complex 3 subunit mu 2).
MGI Description
PHENOTYPE: Homozygous null mice suffer from spontaneous recurrent epileptic seizures, are more susceptible to drug-induced seizures and show impaired GABA release, fewer synaptic vesicles, enhanced long-term potentiation, and abnormal propagation of neuronal excitability via the temporoammonic pathway. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10529
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
23.278M23.280M23.282M23.284M23.286M23.288M23.290M23.292M23.294M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions