Predicted to enable PDZ domain binding activity; microtubule binding activity; and scaffold protein binding activity. Predicted to be involved in several processes, including cytoplasmic microtubule organization; protein localization to microtubule; and regulation of postsynaptic density organization. Predicted to be located in dendrite; neuronal cell body; and postsynaptic density. Predicted to be part of spliceosomal complex. Predicted to be active in dendrite; glutamatergic synapse; and postsynaptic density, intracellular component. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system; nervous system; and retina layer. Human ortholog(s) of this gene implicated in Rothmund-Thomson syndrome. Orthologous to human CRIPT (CXXC repeat containing interactor of PDZ3 domain).
MGI Description
PHENOTYPE: Mice homozygous for a transposon induced allele exhibit embryonic lethality at E8. [provided by MGI curators]