Gene

Arl3

Species
Mus musculus
Symbol
Arl3
Name
ADP-ribosylation factor-like 3
Synonyms
None
Biotype
protein coding gene
Automated Description
Enables GTPase activity; guanyl ribonucleotide binding activity; and magnesium ion binding activity. Involved in several processes, including Golgi to plasma membrane transport; photoreceptor cell development; and protein localization to ciliary membrane. Acts upstream of or within intraciliary transport and smoothened signaling pathway. Located in axoneme; ciliary basal body; and ciliary transition zone. Is expressed in central nervous system; retina nuclear layer; and skin. Used to study autosomal recessive polycystic kidney disease and retinitis pigmentosa 2. Human ortholog(s) of this gene implicated in Joubert syndrome and retinitis pigmentosa 83. Orthologous to human ARL3 (ARF like GTPase 3).
MGI Description
PHENOTYPE: Mice homozygous for a gene trapped allele are born at sub-Mendelian ratios, are small and sickly, fail to thrive, and die by 3 weeks of age exhibiting photoreceptor degeneration and abnormal epithelial cell proliferation and cyst formation in the kidney,liver, and pancreatic tubule structures. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR45697
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
46.520M46.525M46.530M46.535M46.540M46.545M46.550M46.555M46.560M

Sequence Details

Loading...

Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions