Gene

Asb1

Species
Mus musculus
Symbol
Asb1
Name
ankyrin repeat and SOCS box-containing 1
Synonyms
  • 1700029O08Rik
  • 1700054C17Rik
Biotype
protein coding gene
Automated Description
Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to contribute to ubiquitin protein ligase activity. Acts upstream of or within male genitalia development. Predicted to be part of ubiquitin ligase complex. Orthologous to human ASB1 (ankyrin repeat and SOCS box containing 1).
MGI Description
PHENOTYPE: Homozygous mutation of this gene results in spleen hypocellularity, decreased spermatogenesis, and thickening of the skin in male animals. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24173
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensASB110 of 10YesYes  
Rattus norvegicusAsb19 of 9YesYes   
Xenopus tropicalisasb15 of 9YesYes   
Danio rerioasb110 of 10YesYes  
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
Asb2142137242 of 9 
Asb13233543253 of 9 
Asb9334843262 of 9 
Fem1a435736252 of 9 
Ankrd16524341262 of 9 
Fem1al618943302 of 9 

Function - GO Annotations

No function available for that gene

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
abnormal skin morphology
abnormal spermatogenesis
abnormal spleen morphology
abnormal testis morphology
decreased circulating chloride level
enlarged spleen
increased CD4-positive NK T cell number
increased circulating potassium level
small spleen
spleen hypoplasia
Showing 1 - 10 of 11 rows
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

No mapped variant information available
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
Asb1em1Gptallele
Asb1em1(IMPC)Ccpczallele
Yes
Asb1em5Gpt
  • Asb1em5Cd5672
allele
Asb1tm1Wehi
  • Asb-1 -
allele
Yes
Asb1em2Gpt
  • Asb1em1Cflox
allele
Asb1em1Smocallele
Asb1em1Cya
  • Asb1em1
allele
NC_000067.7:g.91468554G>Avariant
SNP
  • 5 prime UTR variant
NC_000067.7:g.91481789G>Avariant
SNP
  • intron variant
NC_000067.7:g.91484130A>Gvariant
SNP
  • 3 prime UTR variant
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Transgenic Alleles

No data available

Models

Model name
Experimental condition
Associated Human Diseases
Associated Phenotypes
Modifier
Source
Asb1em1(IMPC)Ccpcz/Asb1em1(IMPC)Ccpcz [background:] C57BL/6N-Asb1em1(IMPC)Ccpcz/Ccpcz
  • abnormal skin morphology
  • abnormal spleen morphology
MGI
Asb1tm1Wehi/Asb1tm1Wehi [background:] involves: C57BL/6
  • abnormal spermatogenesis
  • abnormal testis morphology
MGI
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Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
91.470M91.472M91.474M91.476M91.478M91.480M91.482M91.484M91.486M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

3 interactor genes based on 3 annotations
Asb1 molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
Asb6Mus musculus
protein
  • biochemical
PMID:32325033
protein
Hoxb8Mus musculus
protein
  • two hybrid
PMID:20211142
protein
Nfe2Mus musculus
protein
  • two hybrid
PMID:20211142
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Genetic Interactions

No data available