Gene

Clstn1

Species
Mus musculus
Symbol
Clstn1
Name
calsyntenin 1
Synonyms
  • 1810034E21Rik
  • alcadein alpha
Biotype
protein coding gene
Automated Description
Predicted to enable X11-like protein binding activity; amyloid-beta binding activity; and kinesin binding activity. Involved in neurotransmitter receptor transport to postsynaptic membrane; regulation of synapse maturation; and vesicle-mediated transport in synapse. Acts upstream of or within positive regulation of synapse assembly; positive regulation of synaptic transmission; and regulation of cell growth. Located in several cellular components, including cell surface; postsynaptic density; and postsynaptic membrane. Is active in glutamatergic synapse and postsynaptic endosome. Is expressed in alimentary system; central nervous system; dorsal root ganglion; olfactory epithelium; and retina. Orthologous to human CLSTN1 (calsyntenin 1).
MGI Description
PHENOTYPE: Juvenile mice homozygous for a null allele show reduced basal excitatory synaptic transmission, abnormal excitatory postsynaptic currents, enhanced NMDA receptor-dependent long term potentiation, and delayed dendritic spine maturation in CA1 hippocampal pyramidal cells. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR14139
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
149.68M149.69M149.70M149.71M149.72M149.73M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions