Gene

Maged1

Species
Mus musculus
Symbol
Maged1
Name
MAGE family member D1
Synonyms
  • 2810433C11Rik
  • 5430405L04Rik
Biotype
protein coding gene
Automated Description
Enables transcription coactivator activity. Involved in positive regulation of branching involved in ureteric bud morphogenesis; regulation of circadian rhythm; and regulation of macromolecule metabolic process. Acts upstream of or within negative regulation of protein localization to nucleus; positive regulation of apoptotic signaling pathway; and regulation of transcription by RNA polymerase II. Located in chromatin and nucleus. Is expressed in several structures, including alimentary system; egg cylinder; genitourinary system; hair follicle; and nervous system. Orthologous to human MAGED1 (MAGE family member D1).
MGI Description
PHENOTYPE: Homozygous null mice display defects in apoptotic signaling affecting hair cycling and neuronal physiology. Mice homozygous for a different knock-out allele exhibit hypoactivity, decreased exploration, social withdrawal, anhedonia, behavioral despair andaltered serotonin levels. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11736
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

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Other Sources
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Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
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      Variant
      Variant type
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCm39
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            93.580M93.581M93.582M93.583M93.584M93.585M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Maged1 molecule type
            Interactor gene
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            Interactor molecule type
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              Genetic Interactions

              Maged1 role
              Maged1 genetic perturbation
              Interactor gene
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              Interactor role
              Interactor genetic perturbation
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