Gene

Glis2

Species
Mus musculus
Symbol
Glis2
Name
GLIS family zinc finger 2
Synonyms
  • MGC:36775
  • Nkl
Biotype
protein coding gene
Automated Description
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of smoothened signaling pathway and regulation of DNA-templated transcription. Acts upstream of or within several processes, including hematopoietic stem cell homeostasis; positive regulation of protein localization to nucleus; and regulation of transcription by RNA polymerase II. Located in non-motile cilium and nuclear speck. Is expressed in several structures, including early conceptus; gut; nervous system; oocyte; and retina layer. Used to study nephronophthisis 7. Human ortholog(s) of this gene implicated in nephronophthisis 7. Orthologous to human GLIS2 (GLIS family zinc finger 2).
MGI Description
PHENOTYPE: Mice homozygous for a fusion allele exhibit decreased kidney weight, kidney atrophy, kidney cysts, and interstitial fibrosis. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR19818
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensGLIS210 of 10YesYes  
Rattus norvegicusGlis29 of 9YesYes   
Xenopus tropicalisglis29 of 9YesYes   
Danio rerioglis2b10 of 10YesYes  
Danio rerioglis2a4 of 10NoYes  
Drosophila melanogastersug6 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
abnormal kidney morphology
abnormal renal glomerular capsule morphology
albuminuria
decreased kidney weight
dilated renal tubule
glomerulonephritis
glomerulosclerosis
increased blood urea nitrogen level
increased circulating creatinine level
increased glomerular capsule space
Showing 1 - 10 of 26 rows
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

No mapped variant information available
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
Glis2em1Smoc
  • Glis2em1Smoc
allele
Glis2em1Gpt
  • Glis2em1Cflox
allele
Glis2tm1Tre
  • Glis2lacZ
allele
YesYes
Glis2tm1Amj
  • Glis2mut
allele
Yes
Glis2tm1a(EUCOMM)Hmguallele
Glis2em13Gpt
  • Glis2em13Cd887
allele
NC_000082.7:g.4416922G>Avariant
SNP
  • intron variant
NC_000082.7:g.4418322A>Gvariant
SNP
  • intron variant
NC_000082.7:g.4418762G>Avariant
SNP
  • intron variant
NC_000082.7:g.4428906G>Tvariant
SNP
  • intron variant
Showing 1 - 10 of 640 rows
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Transgenic Alleles

No data available

Models

Model name
Experimental condition
Associated Human Diseases
Associated Phenotypes
Modifier
Source
Glis2tm1Tre/Glis2tm1Tre [background:] B6.129P2-Glis2tm1Tre
  • abnormal kidney morphology
  • decreased kidney weight
MGI
Glis2tm1Amj/Glis2tm1Amj [background:] involves: 129P2/OlaHsd * C57BL/6
  • abnormal renal glomerular capsule morphology
  • albuminuria
MGI
Showing 1 - 2 of 2 rows
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Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
4.415M4.420M4.425M4.430M4.435M4.440M

Sequence Details

Transcript: Mode:

Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

2 interactor genes based on 4 annotations
Glis2 molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
Ctbp1Mus musculus
protein
  • two hybrid
PMID:16326862
protein
Ctbp1Mus musculus
protein
  • affinity chromatography technology
PMID:16326862
protein
Ctbp1Mus musculus
protein
  • pull down
PMID:16326862
protein
Hdac3Mus musculus
protein
  • affinity chromatography technology
PMID:16326862
Showing 1 - 4 of 4 rows
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Genetic Interactions

No data available