Version: 8.0.0
Date: Tue Jan 28 2025
Gpr107
Mus musculusMGI:2139054
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Gpr107

Species
Mus musculus
Symbol
Gpr107
Name
G protein-coupled receptor 107
Synonyms
  • AI790205
  • expressed sequence AI790205
Biotype
protein coding gene
Automated Description
Enables clathrin heavy chain binding activity. Acts upstream of or within clathrin-dependent endocytosis. Located in clathrin-coated vesicle and early endosome. Orthologous to human GPR107 (G protein-coupled receptor 107).
MGI Description
PHENOTYPE: Homozygous inactivation of this gene causes complete embryonic lethality during organogenesis, associated with reduced expression of genes implicated in the cubilin-megalin multi-ligand endocytic receptor complex. Homozygous null MEFs show defects in receptor-mediated endocytosis and recycling. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR21229
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensGPR10710 of 10YesYes☑☑☑☑☑☑☑☑☑☑  
Rattus norvegicusGpr1079 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Xenopus tropicalisgpr1075 of 9YesYes☑ ☐☐☑☑☐☑☑☐  
Danio reriogpr1079 of 10YesYes☑ ☐☑☑☑☑☑☑☑ ☑
Drosophila melanogasterCG121218 of 9YesYes☑ ☑☑☐☑☑☑☑☑  
Caenorhabditis elegansC15H9.58 of 9YesNo☑ ☑☑☐☑☑☑☑☑  
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
Gpr108155467517 of 9☑☐☑☐☑☑☑☑☑ 
Tmem87b243339223 of 9☑☐☐☐☐☐☑☑☐ 
Tmem87a336041233 of 9☑☐☐☐☐☐☑☑☐ 

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
abnormal vesicle-mediated transport
decreased embryo size
embryonic lethality during organogenesis, complete penetrance
preweaning lethality, complete penetrance
Showing 1 - 4 of 4 rows
per page

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume
Species
Gene
Association
Disease Qualifier
Disease
Evidence
Source
Based On
References
No records match query. Try removing filters.
Showing 0 - 0 of 0 rows
per page

    Alleles and Variants

    Genome location
    Assembly version
    GRCm39
    Viewer Help
    Data currently unavailable; sequence viewer under construction
    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
    Gpr107tm1a(KOMP)Wtsiallele
    		Yes
    Gpr107tm1Brs
    • Gpr107-
    		allele
    		Yes
    NC_000068.8:g.31044340C>Tvariant
    SNP
    • intron variant
    NC_000068.8:g.31044517A>Gvariant
    SNP
    • intron variant
    NC_000068.8:g.31048802A>Tvariant
    SNP
    • intron variant
    NC_000068.8:g.31049250T>Cvariant
    SNP
    • intron variant
    NC_000068.8:g.31049972G>Avariant
    SNP
    • intron variant
    NC_000068.8:g.31046612C>Tvariant
    SNP
    • intron variant
    NC_000068.8:g.31051015G>Avariant
    SNP
    • intron variant
    NC_000068.8:g.31047001A>Cvariant
    SNP
    • intron variant
    Showing 1 - 10 of 1,956 rows
    per page
    View detailed Alleles/Variants information
    Download all Alleles/Variants for all genes of the species

    Transgenic Alleles

    No data available

    Models

    Model name
    Experimental condition
    Associated Human Diseases
    Associated Phenotypes
    Modifier
    Source
    Gpr107tm1a(KOMP)Wtsi/Gpr107tm1a(KOMP)Wtsi [background:] C57BL/6N-Gpr107tm1a(KOMP)Wtsi/Wtsi
    • preweaning lethality, complete penetrance
    		MGI
    Gpr107tm1Brs/Gpr107tm1Brs [background:] involves: 129S6/SvEvTac
    • abnormal vesicle-mediated transport
    • decreased embryo size
    		MGI
    Showing 1 - 2 of 2 rows
    per page

    Sequence Feature Viewer

    Genome location
    Assembly version
    GRCm39
    Viewer Help
    Data currently unavailable; sequence viewer under construction

    Sequence Details

    Loading...

    Expression

    Primary Sources
    None
    Other Sources
    Must provide at least one subject
    Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

    Molecular Interactions

    2 interactor genes based on 2 annotations
    Gpr107 molecule type
    Interactor gene
    Interactor species
    Interactor molecule type
    Detection methods
    Source
    Reference
    protein
    		Prex2Mus musculus
    protein
    • biochemical
    		PMID:32325033
    protein
    		Sting1Mus musculus
    protein
    • proximity labelling technology
    		PMID:32554809
    Showing 1 - 2 of 2 rows
    per page

    Genetic Interactions

    No data available