Enables chloride channel activity and ligand-gated monoatomic ion channel activity. Acts upstream of or within chloride transport. Located in plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; immune system; skin; and telencephalon. Orthologous to human CLCA2 (chloride channel accessory 2).
MGI Description
PHENOTYPE: Mice homozygous for a targeted null mutation exhibit increases in liver weight to body weight ratio and hepatocyte hypertrophy; one incidence of multifocal hepatic necrosis. [provided by MGI curators]