Gene

Tdrd7

Species
Mus musculus
Symbol
Tdrd7
Name
tudor domain containing 7
Synonyms
  • 5730495N10Rik
  • AI447470
Biotype
protein coding gene
Automated Description
Predicted to enable mRNA binding activity. Involved in lens fiber cell differentiation; lens morphogenesis in camera-type eye; and spermatogenesis. Acts upstream of or within germ cell development. Located in P granule and chromatoid body. Part of ribonucleoprotein complex. Is expressed in several structures, including central nervous system; eye; germ cell of testis; and olfactory epithelium. Human ortholog(s) of this gene implicated in cataract 36. Orthologous to human TDRD7 (tudor domain containing 7).
MGI Description
PHENOTYPE: Homozygous inactivation of this gene causes arrest of spermatogenesis, male sterility, glaucoma, and cataracts. Aging mice homozygous for an ENU-induced (null) allele show additional ocular phenotypes including an enlarged anterior chamber, lens extrusion, a flat iris, uveitis, and optic neuropathy. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR22948
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
abnormal iris morphology
abnormal lens fiber morphology
abnormal lens morphology
abnormal male reproductive system physiology
arrest of spermatogenesis
cataract
increased eye anterior chamber depth
increased male germ cell apoptosis
male infertility
ocular hypertension
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Disease Associations

Cases where the expected disease association was NOT found
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Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
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45.97M45.98M45.99M46.00M46.01M46.02M46.03M

Sequence Details

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Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions