Gene

Zfand2a

Species
Mus musculus
Symbol
Zfand2a
Name
zinc finger, AN1-type domain 2A
Synonyms
  • AA407930
  • Airap
Biotype
protein coding gene
Automated Description
Predicted to enable zinc ion binding activity. Acts upstream of or within cellular response to arsenic-containing substance and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Part of proteasome complex. Is expressed in cerebral cortex. Orthologous to human ZFAND2A (zinc finger AN1-type containing 2A).
MGI Description
PHENOTYPE: Homozygous mutant mouse embryonic fibroblasts accumulate more polyubiquitylated proteins than wild-type cells and display higher levels of stress when exposed to arsenite, while isolated proteasomes are relatively impaired in substrate degradation in vitro. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR14677
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensZFAND2A10 of 10YesYes  
Rattus norvegicusZfand2a9 of 9YesYes   
Xenopus tropicaliszfand2a3 of 9YesYes   
Danio reriozfand2a4 of 10YesNo  
Drosophila melanogasterCG127955 of 9YesNo   
Caenorhabditis elegansaip-18 of 9YesYes   
Saccharomyces cerevisiaeCUZ13 of 9YesNo   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
Zfand2b116570547 of 9 
Zfand1219033233 of 9 

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
abnormal cell physiology
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Transgenic Alleles

No data available

Models

Model name
Experimental condition
Associated Human Diseases
Associated Phenotypes
Modifier
Source
Zfand2aGt(XM071)Byg/Zfand2aGt(XM071)Byg [background:] involves: 129P2/OlaHsd
  • abnormal cell physiology
MGI
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Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
139.458M139.460M139.462M139.464M139.466M139.468M139.470M

Sequence Details

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Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

8 interactor genes based on 14 annotations
Zfand2a molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
Hspa8Mus musculus
protein
  • affinity chromatography technology
PMID:16973439
protein
PSMA1Homo sapiens
protein
  • pull down
PMID:18467495
protein
Psma1Mus musculus
protein
  • biochemical
PMID:16973439
protein
Psma1Mus musculus
protein
  • biochemical
PMID:16973439
protein
Psma1Mus musculus
protein
  • affinity chromatography technology
PMID:16973439
protein
Psma1Mus musculus
protein
  • affinity chromatography technology
PMID:16973439
protein
Psmd1Mus musculus
protein
  • biochemical
PMID:16973439
protein
Psmd1Mus musculus
protein
  • affinity chromatography technology
PMID:16973439
protein
Psmd2Mus musculus
protein
  • affinity chromatography technology
PMID:16973439
protein
Psmd2Mus musculus
protein
  • affinity chromatography technology
PMID:16973439
Showing 1 - 10 of 14 rows
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Genetic Interactions

No data available