Predicted to enable oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor and steroid dehydrogenase activity. Predicted to be involved in lipid metabolic process. Predicted to act upstream of or within positive regulation of lipid biosynthetic process. Located in lipid droplet. Orthologous to human HSD17B13 (hydroxysteroid 17-beta dehydrogenase 13).
MGI Description
PHENOTYPE: Male mice homozygous for a null allele exhibit hepatic steatosis, increased liver triglyceride levels, increased lipogenesis, decreased fatty acid beta-oxidaton, and liver inflammation. [provided by MGI curators]