Version: 8.0.0
Date: Tue Jan 28 2025
Whamm
Mus musculusMGI:2142282
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Whamm

Species
Mus musculus
Symbol
Whamm
Name
WAS protein homolog associated with actin, golgi membranes and microtubules
Synonyms
  • BB081391
  • expressed sequence BB081391
Biotype
protein coding gene
Automated Description
Predicted to enable Arp2/3 complex binding activity; microtubule binding activity; and small GTPase binding activity. Involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Predicted to be located in Golgi membrane and cytosol. Predicted to be active in endoplasmic reticulum-Golgi intermediate compartment membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and integumental system. Used to study Fanconi syndrome. Orthologous to human WHAMM (WASP homolog associated with actin, golgi membranes and microtubules).
MGI Description
PHENOTYPE: Mice homozygous for a knock-out allele exhibit male-specific abnormalities in kidney proximal tubule structure and reabsorption function with increased urinary levels of albumin, glucose, HAVCR1, phosphate, potassium and amino acids, and altered autophagy in kidney tissue. Mouse embryonic fibroblasts show altered autophagosome organization and actin recruitment. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23330
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
No records match query. Try removing filters.
Showing 0 - 0 of 0 rows
per page

    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
    Evidence
    Source
    Based On
    References
    No records match query. Try removing filters.
    Showing 0 - 0 of 0 rows
    per page

      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
      Has Disease Annotations
      Has Phenotype Annotations
      No records match query. Try removing filters.
      Showing 0 - 0 of 0 rows
      per page
        Download all Alleles/Variants for all genes of the species

        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
        Has Disease Annotations
        Has Phenotype Annotations
        No records match query. Try removing filters.
        Showing 0 - 0 of 0 rows
        per page

          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
          Modifier
          Source
          No records match query. Try removing filters.
          Showing 0 - 0 of 0 rows
          per page

            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCm39
            Viewer Help
            81.225M81.230M81.235M81.240M81.245M

            Sequence Details

            Loading...

            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Whamm molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
            Reference
            No records match query. Try removing filters.
            Showing 0 - 0 of 0 rows
            per page

              Genetic Interactions

              Whamm role
              Whamm genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
              Source
              Reference
              No records match query. Try removing filters.
              Showing 0 - 0 of 0 rows
              per page