Version: 8.0.0
Date: Tue Jan 28 2025
Whamm
Mus musculusMGI:2142282
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Whamm

Species
Mus musculus
Symbol
Whamm
Name
WAS protein homolog associated with actin, golgi membranes and microtubules
Synonyms
  • BB081391
  • expressed sequence BB081391
Biotype
protein coding gene
Automated Description
Predicted to enable Arp2/3 complex binding activity; microtubule binding activity; and small GTPase binding activity. Involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Predicted to be located in Golgi membrane and cytosol. Predicted to be active in endoplasmic reticulum-Golgi intermediate compartment membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and integumental system. Used to study Fanconi syndrome. Orthologous to human WHAMM (WASP homolog associated with actin, golgi membranes and microtubules).
MGI Description
PHENOTYPE: Mice homozygous for a knock-out allele exhibit male-specific abnormalities in kidney proximal tubule structure and reabsorption function with increased urinary levels of albumin, glucose, HAVCR1, phosphate, potassium and amino acids, and altered autophagy in kidney tissue. Mouse embryonic fibroblasts show altered autophagosome organization and actin recruitment. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23330
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
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          Sequence Feature Viewer

          Genome location
          Assembly version
          GRCm39
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Whamm molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            Whamm role
            Whamm genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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