Gene

Plekho2

Species
Mus musculus
Symbol
Plekho2
Name
pleckstrin homology domain containing, family O member 2
Synonyms
  • AI840980
  • expressed sequence AI840980
Biotype
protein coding gene
Automated Description
Acts upstream of or within macrophage apoptotic process. Orthologous to human PLEKHO2 (pleckstrin homology domain containing O2).
MGI Description
PHENOTYPE: Mice homozygous for a null allele exhibit reduced macrophages in the spleen, blood and peritoneal cavity due to increased apoptosis. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR15871
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensPLEKHO29 of 10YesYes  
Rattus norvegicusPlekho29 of 9YesYes   
Xenopus tropicalisplekho29 of 9YesYes   
Danio rerioplekho29 of 10YesYes  
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
Plekho1150942283 of 9 

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
decreased macrophage cell number
increased macrophage apoptosis
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

No mapped variant information available
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
Plekho2em1(IMPC)Bayallele
Plekho2em1Lzhnallele with one associated variant
deletion
  • frameshift variant
Yes
NC_000075.7:g.65466966C>Tvariant
SNP
  • intron variant
NC_000075.7:g.65468220G>Cvariant
SNP
  • intron variant
NC_000075.7:g.65468809G>Avariant
SNP
  • intron variant
NC_000075.7:g.65465040G>Avariant
SNP
  • intron variant
NC_000075.7:g.65459972T>Cvariant
SNP
  • 3 prime UTR variant
NC_000075.7:g.65459986G>Tvariant
SNP
  • non coding transcript exon variant
NC_000075.7:g.65461164T>Avariant
SNP
  • non coding transcript exon variant
NC_000075.7:g.65462623A>Tvariant
SNP
  • 3 prime UTR variant
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Transgenic Alleles

No data available

Models

Model name
Experimental condition
Associated Human Diseases
Associated Phenotypes
Modifier
Source
Plekho2em1Lzhn/Plekho2em1Lzhn [background:] C57BL/6-Plekho2em1Lzhn
  • decreased macrophage cell number
  • increased macrophage apoptosis
MGI
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Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
65.460M65.465M65.470M65.475M65.480M65.485M

Sequence Details

Transcript: Mode:

Expression

Primary Sources
None
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

2 interactor genes based on 2 annotations
Plekho2 molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
Sting1Mus musculus
protein
  • proximity labelling technology
PMID:32554809
protein
YwhaeMus musculus
protein
  • biochemical
PMID:32325033
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Genetic Interactions

No data available