Predicted to enable NuA4 histone acetyltransferase complex binding activity; chromatin binding activity; and methylated histone binding activity. Acts upstream of or within embryonic skeletal system development. Predicted to be part of NuA4 histone acetyltransferase complex and nucleosome. Predicted to be active in nucleus and site of double-strand break. Is expressed in several structures, including cerebral cortex; early conceptus; gonad; neural retina; and skeletal muscle tissue. Orthologous to human MBTD1 (mbt domain containing 1).
MGI Description
PHENOTYPE: Mice homozygous for a knock-out allele exhibit neonatal lethality and severe abnormalities in hematopoietic stem cell function and skeletal formation. [provided by MGI curators]