Gene

Akr1c18

Species
Mus musculus
Symbol
Akr1c18
Name
aldo-keto reductase family 1, member C18
Synonyms
  • 20alpha-HSD
  • 20alpha-hydroxysteroid dehydrogenase
Biotype
protein coding gene
Automated Description
Enables 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity. Acts upstream of or within parturition and progesterone catabolic process. Predicted to be located in cytoplasm and nucleus. Predicted to be active in cytosol. Is expressed in several structures, including adrenal gland; brain; female reproductive system; and lung. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; T-cell acute lymphoblastic leukemia; and leukemia. Orthologous to human AKR1C3 (aldo-keto reductase family 1 member C3).
MGI Description
PHENOTYPE: Mice homozygous for mutations in this gene display prolonged pregnancies and decreased number of pups. Some cannot induce parturition while others are able to give birth but show a prolonged estrous cycle. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11732
No data available
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

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        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCm39
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            4.184M4.186M4.188M4.190M4.192M4.194M4.196M4.198M4.200M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Akr1c18 molecule type
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              Genetic Interactions

              Akr1c18 role
              Akr1c18 genetic perturbation
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