Version: 8.0.0
Date: Tue Jan 28 2025
Ppif
Mus musculusMGI:2145814
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Ppif

Species
Mus musculus
Symbol
Ppif
Name
peptidylprolyl isomerase F (cyclophilin F)
Synonyms
  • AW457192
  • CyP-D
Biotype
protein coding gene
Automated Description
Predicted to enable cyclosporin A binding activity; peptide binding activity; and peptidyl-prolyl cis-trans isomerase activity. Involved in several processes, including regulation of mitochondrial membrane permeability involved in programmed necrotic cell death; regulation of proton transport; and response to ischemia. Acts upstream of or within several processes, including apoptotic mitochondrial changes; mitochondrial depolarization; and skeletal muscle fiber differentiation. Located in mitochondrion. Part of mitochondrial permeability transition pore complex. Is expressed in lower jaw tooth and tooth. Orthologous to human PPIF (peptidylprolyl isomerase F).
MGI Description
PHENOTYPE: Homozygous inactivation of this gene results in abnormal mitochondrial physiology and a significantly decreased infarction size following ischemia/reperfusion-induced cardiac or brain injury. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11071
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          GRCm39
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Ppif molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            Ppif role
            Ppif genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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