Version: 8.0.0Date: Tue Jan 28 2025
Gene
Scrib
- Species
- Mus musculus
- Symbol
- Scrib
- Name
- scribbled planar cell polarity
- Synonyms
- AI118201
- circletail
- Biotype
- protein coding gene
- Automated Description
- Predicted to enable protein kinase binding activity and signaling adaptor activity. Involved in several processes, including establishment of T cell polarity; negative regulation of activated T cell proliferation; and synaptic vesicle cycle. Acts upstream of or within several processes, including nervous system development; post-anal tail morphogenesis; and wound healing. Located in several cellular components, including basolateral plasma membrane; immunological synapse; and myelin sheath abaxonal region. Is expressed in several structures, including embryo mesenchyme; genitourinary system; gut; nervous system; and skin. Used to study prostate cancer. Orthologous to human SCRIB (scribble planar cell polarity protein).
- MGI Description
- PHENOTYPE: Mice homozygous for a null allele display partial prenatal lethality. Mice homozygous for spontaneous or induced alleles exhibit craniofacial or neural tube defects. [provided by MGI curators]
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR23119
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- Other Sources
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
No data available
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- Chr15:75919011...75941633 - (22.62 kb)
- Assembly version
- GRCm39
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.