Version: 8.0.0
Date: Tue Jan 28 2025
Egflam
Mus musculusMGI:2146149
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Egflam

Species
Mus musculus
Symbol
Egflam
Name
EGF-like, fibronectin type III and laminin G domains
Synonyms
  • AU040377
  • expressed sequence AU040377
Biotype
protein coding gene
Automated Description
Enables glycosaminoglycan binding activity. Acts upstream of or within extracellular matrix organization and positive regulation of cell-substrate adhesion. Located in basement membrane and interstitial matrix. Is active in photoreceptor ribbon synapse. Is expressed in hair follicle and rib. Orthologous to human EGFLAM (EGF like, fibronectin type III and laminin G domains).
MGI Description
PHENOTYPE: Homozygous null mutants are viable and fertile under normal conditions. They exhibit abnormal photoreceptor ribbon synapses, resulting in alteration in synaptic signal transmission and visual function. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR15036
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensEGFLAM10 of 10YesYes☑☑☑☑☑☑☑☑☑☑  
Rattus norvegicusEgflam9 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Xenopus tropicalisegflam9 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Drosophila melanogasterSP23536 of 9YesYes☑ ☑☐☐☑☑☐☑☑  
Caenorhabditis elegansT19D12.66 of 9YesYes☐ ☑☑☑☑☐☐☑☑  
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
Hspg21117241262 of 9☑☐☐☐☐☐☐☑☐ 
Agrn2114440262 of 9☑☐☐☐☐☐☐☑☐ 
Lama53118331202 of 9☑☐☐☐☐☐☐☑☐ 
Lama34101734192 of 9☑☐☐☐☐☐☐☑☐ 
Lama1583937222 of 9☑☐☐☐☐☐☐☑☐ 
Lama2685831192 of 9☑☐☐☐☐☐☐☑☐ 
Lama4769936222 of 9☑☐☐☐☐☐☐☑☐ 

Function - GO Annotations

No function available for that gene

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
abnormal cone electrophysiology
abnormal eye physiology
abnormal retina cone cell morphology
abnormal retina rod cell morphology
abnormal rod electrophysiology
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Disease Associations

Cases where the expected disease association was NOT found
all annotationsall disease by infectious agentbacterial infectious diseasefungal infectious diseaseparasitic infectious diseaseviral infectious diseaseall disease of anatomical entitycardiovascular system diseasecentral nervous system diseaseendocrine system diseasegastrointestinal system diseasehematopoietic system diseaseimmune system diseaseintegumentary system diseasemusculoskeletal system diseaseperipheral nervous system diseasereproductive system diseaserespiratory system diseasesensory system diseasethoracic diseaseurinary system diseaseall disease of cellular proliferationbenign neoplasmcancerpre-malignant neoplasmall genetic diseasechromosomal diseasemonogenic diseasepolygenic diseaseall other diseasedisease of mental healthdisease of metabolismphysical disordersyndrome
Egflam (Mmu)
Cell color indicative of annotation volume
No data available

Alleles and Variants

Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
No records match query. Try removing filters.
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    Download all Alleles/Variants for all genes of the species

    Transgenic Alleles

    No data available

    Models

    Model name
    Experimental condition
    Associated Human Diseases
    Associated Phenotypes
    Modifier
    Source
    Egflamtm1Tfir/Egflamtm1Tfir [background:] involves: 129S6/SvEvTac
    • abnormal cone electrophysiology
    • abnormal eye physiology
    		MGI
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    Sequence Feature Viewer

    Genome location
    Assembly version
    GRCm39
    Viewer Help
    7.24M7.26M7.28M7.30M7.32M7.34M7.36M7.38M7.40M7.42M

    Sequence Details

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    Expression

    Primary Sources
    Other Sources
    all annotationsall anatomical structuresalimentary part of gastrointestinal systemchemosensory systemcirculatory systemendocrine systemexocrine systemhemolymphoid systemhepatobiliary systemintegumental systemmechanosensory systemmusculoskeletal systemnervous systemrenal systemreproductive systemrespiratory systemsensory systemvestibulo-auditory systemvisual systemendodermectodermmesodermmesenchymeadipose tissueappendageentire extraembryonic componentimaginal precursorpharyngeal archotherall stagesembryo stagepost embryonic, pre-adultpost-juvenile adult stageall cellular componentsextracellular regionplasma membranesynapsecell junctioncell projectioncytoplasmic vesicleendosomevacuolegolgi apparatusendoplasmic reticulumcytosolmitochondrionnucleuschromosomecytoskeletonprotein-containing complexother locations
    Egflam (Mmu)
    Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

    Molecular Interactions

    6 interactor genes based on 12 annotations
    Egflam molecule type
    Interactor gene
    Interactor species
    Interactor molecule type
    Detection methods
    Source
    Reference
    protein
    		Ctbp2Mus musculus
    protein
    • confocal microscopy
    		PMID:18641643
    protein
    		Dag1Mus musculus
    protein
    • biochemical
    		PMID:32325033
    protein
    		Dag1Mus musculus
    protein
    • pull down
    		PMID:18641643
    protein
    		Dag1Mus musculus
    protein
    • pull down
    		PMID:18641643
    protein
    		Dag1Mus musculus
    protein
    • confocal microscopy
    		PMID:18641643
    protein
    		DmdMus musculus
    protein
    • confocal microscopy
    		PMID:18641643
    protein
    		GPR179Homo sapiens
    protein
    • pull down
    		PMID:30282023
    protein
    		GPR179Homo sapiens
    protein
    • pull down
    		PMID:30282023
    protein
    		GPR179Homo sapiens
    protein
    • anti tag coimmunoprecipitation
    		PMID:30282023
    protein
    		Gpr179Mus musculus
    protein
    • proximity ligation assay
    		PMID:30282023
    Showing 1 - 10 of 12 rows
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    Genetic Interactions

    No data available