Gene

Dock10

Species
Mus musculus
Symbol
Dock10
Name
dedicator of cytokinesis 10
Synonyms
  • 9330153B10Rik
  • A630054M16Rik
Biotype
protein coding gene
Automated Description
Enables guanyl-nucleotide exchange factor activity and small GTPase binding activity. Involved in several processes, including dendritic spine morphogenesis; marginal zone B cell differentiation; and regulation of postsynapse assembly. Located in dendritic spine. Is active in glutamatergic synapse and postsynapse. Is expressed in several structures, including central nervous system; endocrine gland; retina; thymus primordium; and trigeminal nerve. Orthologous to human DOCK10 (dedicator of cytokinesis 10).
MGI Description
PHENOTYPE: Mice homozygous for a knock-out allele exhibit a reduction of B cell numbers in secondary lymphoid organs. Follicular B cells show membrane CD23 overexpression. Homozygous KO also leads to a thinner spleen marginal zone B cell region and a decreased thymic CD8+ T cell percentage. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23317
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
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      Alleles and Variants

      Allele/Variant Symbol
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCm39
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            80.50M80.55M80.60M80.65M80.70M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Dock10 molecule type
            Interactor gene
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              Genetic Interactions

              Dock10 role
              Dock10 genetic perturbation
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