Gene

Dlk2

Species
Mus musculus
Symbol
Dlk2
Name
delta like non-canonical Notch ligand 2
Synonyms
  • AI413481
  • DLK-2
Biotype
protein coding gene
Automated Description
Enables identical protein binding activity. Involved in regulation of fat cell differentiation. Acts upstream of or within negative regulation of Notch signaling pathway. Predicted to be located in membrane. Is expressed in several structures, including alimentary system; brain; limb mesenchyme; metanephros; and musculoskeletal system. Orthologous to human DLK2 (delta like non-canonical Notch ligand 2).
MGI Description
PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased anxiety and depressive-like behaviors, altered vulnerability to restraint stress, and an impaired behavioral response to the anxiolytic action of alprazolam. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24044
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
46.609M46.610M46.611M46.612M46.613M46.614M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions