Enables identical protein binding activity. Involved in regulation of fat cell differentiation. Acts upstream of or within negative regulation of Notch signaling pathway. Predicted to be located in membrane. Is expressed in several structures, including alimentary system; brain; limb mesenchyme; metanephros; and musculoskeletal system. Orthologous to human DLK2 (delta like non-canonical Notch ligand 2).
MGI Description
PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased anxiety and depressive-like behaviors, altered vulnerability to restraint stress, and an impaired behavioral response to the anxiolytic action of alprazolam. [provided by MGI curators]