Predicted to enable chloride channel activity. Acts upstream of or within positive regulation of osteoblast differentiation and regulation of mitochondrial membrane potential. Located in mitochondrion and nucleus. Is expressed in brain; early conceptus; and heart valve. Orthologous to human CLIC1 (chloride intracellular channel 1).
MGI Description
PHENOTYPE: Mice homozygous for disruptions in this gene display abnormal platelet number, activation and aggregation and prolonged bleeding time. [provided by MGI curators]