Enables crossover junction DNA endonuclease activity. Involved in telomere maintenance via recombination. Acts upstream of or within female meiosis sister chromatid cohesion; meiosis I; and spermatogenesis. Located in nucleus. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group O and hereditary breast ovarian cancer syndrome. Orthologous to human RAD51C (RAD51 paralog C).
MGI Description
PHENOTYPE: Mice homozygous for a null mutation display embryonic lethality. Mice carrying a null and a hypomorphic allele have partial penetrance of male and female infertility due to defects in meiosis. [provided by MGI curators]