Predicted to enable phospholipase activity. Acts upstream of or within sperm mitochondrion organization. Predicted to be active in cytoplasm. Is expressed in several structures, including cerebral cortex; foregut; ganglia; nose; and tooth. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 28. Orthologous to human DDHD1 (DDHD domain containing 1).
MGI Description
PHENOTYPE: Mice homozygous for a null allele show reduced testis weight, oligozoospermia, teratozoospermia, and male subfertility. Sperm defects include a disorganized mitochondrial structure, an abnormal gap between the middle and principal pieces, and hairpin flagellum leading to impaired sperm motility. [provided by MGI curators]