Predicted to enable SH3 domain binding activity. Predicted to contribute to guanyl-nucleotide exchange factor activity. Acts upstream of or within actin filament-based process and phagocytosis. Part of guanyl-nucleotide exchange factor complex. Is active in glutamatergic synapse and postsynapse. Is expressed in several structures, including genitourinary system; hemolymphoid system gland; nervous system; retina; and vibrissa. Orthologous to human ELMO1 (engulfment and cell motility 1).
MGI Description
PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired Sertoli cell phagocytosis of apoptotic male germ cells. Mice homozygous for an ENU-induced allele exhibit decreased CD4+ T cells.
[provided by MGI curators]