Version: 8.0.0
Date: Tue Jan 28 2025
Dicer1
Mus musculusMGI:2177178
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Dicer1

Species
Mus musculus
Symbol
Dicer1
Name
dicer 1, ribonuclease type III
Synonyms
  • 1110006F08Rik
  • D12Ertd7e
Biotype
protein coding gene
Automated Description
Enables miRNA binding activity. Involved in several processes, including nervous system development; regulation of macromolecule metabolic process; and regulation of nervous system development. Acts upstream of or within several processes, including circulatory system development; negative regulation of macromolecule metabolic process; and nervous system development. Located in cytoplasm. Part of RISC complex and RISC-loading complex. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Used to study DiGeorge syndrome; dilated cardiomyopathy; and ovarian cancer. Human ortholog(s) of this gene implicated in DICER1 syndrome; gastrointestinal system cancer (multiple); multinodular goiter; nephroma; and pleuropulmonary blastoma. Orthologous to human DICER1 (dicer 1, ribonuclease III).
MGI Description
PHENOTYPE: Mutation of this locus results in arrest of early embryonic development. Inducible muscle-specific KO results in impaired muscle regeneration. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR14950
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
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          Sequence Feature Viewer

          Genome location
          Assembly version
          GRCm39
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Dicer1 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
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            Genetic Interactions

            Dicer1 role
            Dicer1 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
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