Gene

Nup155

Species
Mus musculus
Symbol
Nup155
Name
nucleoporin 155
Synonyms
  • D930027M19Rik
  • mKIAA0791
Biotype
protein coding gene
Automated Description
Predicted to be a structural constituent of nuclear pore. Acts upstream of or within with a positive effect on miRNA processing and protein localization to nucleus. Acts upstream of or within atrial cardiac muscle cell action potential; mRNA export from nucleus; and protein import into nucleus. Located in nuclear envelope. Human ortholog(s) of this gene implicated in familial atrial fibrillation. Orthologous to human NUP155 (nucleoporin 155).
MGI Description
PHENOTYPE: Homozygotes for a gene trap allele die prior to E8.5 while heterozygotes develop atrial fibrillation with shortened action potential duration. Homozygotes for a knock-out allele show complete embryonic lethality prior to organogenesis with failure of blastocysts to hatch from the zona pellucida and form in vitro outgrowths. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10350
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
8.140M8.145M8.150M8.155M8.160M8.165M8.170M8.175M8.180M8.185M8.190M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions