Version: 8.0.0
Date: Tue Jan 28 2025
Pfkfb3
Mus musculusMGI:2181202
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Pfkfb3

Species
Mus musculus
Symbol
Pfkfb3
Name
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
Synonyms
  • E330010H22Rik
  • RIKEN cDNA E330010H22 gene
Biotype
protein coding gene
Automated Description
Predicted to enable 6-phosphofructo-2-kinase activity and fructose-2,6-bisphosphate 2-phosphatase activity. Acts upstream of or within several processes, including glial cell differentiation; glycolytic process; and motor behavior. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; integumental system; nervous system; sensory organ; and skeleton. Used to study extrinsic cardiomyopathy. Orthologous to human PFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3).
MGI Description
PHENOTYPE: Homozygous null mice display embryonic lethality before E8. Inducible endothelial cell-specific homozygous knockout affects glycolysis in muscle ECs, reducing their proliferation rate and their macrophage signaling, which in turn impairs revascularization and thus muscle regeneration after ischemic injury. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10606
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
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    Disease Associations

    Cases where the expected disease association was NOT found
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    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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        Models

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          Sequence Feature Viewer

          Genome location
          Assembly version
          GRCm39
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Pfkfb3 molecule type
          Interactor gene
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            Genetic Interactions

            Pfkfb3 role
            Pfkfb3 genetic perturbation
            Interactor gene
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            Interactor role
            Interactor genetic perturbation
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            Phenotype or trait
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