Gene

Fgd4

Species
Mus musculus
Symbol
Fgd4
Name
FYVE, RhoGEF and PH domain containing 4
Synonyms
  • 9330209B17Rik
  • Frabin
Biotype
protein coding gene
Automated Description
Predicted to enable actin filament binding activity and guanyl-nucleotide exchange factor activity. Acts upstream of or within lamellipodium assembly and microspike assembly. Located in filopodium and lamellipodium. Is expressed in hand; nervous system; pancreas; and sensory organ. Used to study Charcot-Marie-Tooth disease type 4H. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4H. Orthologous to human FGD4 (FYVE, RhoGEF and PH domain containing 4).
MGI Description
PHENOTYPE: Mice homozygous for a knock-out allele display dysmyelination in early peripheral nerve development, followed by severe myelin abnormalities, demyelinationn, nervous system electrophysiological deficits, and decreased grip strength at later stages. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12673
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
16.24M16.26M16.28M16.30M16.32M16.34M16.36M16.38M16.40M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions