Gene

Farp2

Species
Mus musculus
Symbol
Farp2
Name
FERM, RhoGEF and pleckstrin domain protein 2
Synonyms
  • AI465173
  • BC009153
Biotype
protein coding gene
Automated Description
Enables guanyl-nucleotide exchange factor activity. Involved in several processes, including osteoclast differentiation; podosome assembly; and regulation of integrin activation. Acts upstream of or within hair cycle process. Predicted to be located in cytoplasm. Is expressed in central nervous system; liver; retina; and testis. Orthologous to human FARP2 (FERM, ARH/RhoGEF and pleckstrin domain protein 2).
MGI Description
PHENOTYPE: Mice homozygous for a knock-out allele exhibit slight increase in bone volumetrics and reduced osteoclast differentiation from BMDMs cultured with M-CSF and RANKL [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR45858
No data available
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
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      Variant
      Variant type
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCm39
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            93.44M93.45M93.46M93.47M93.48M93.49M93.50M93.51M93.52M93.53M93.54M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Farp2 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
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              Genetic Interactions

              Farp2 role
              Farp2 genetic perturbation
              Interactor gene
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              Interactor genetic perturbation
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              Phenotype or trait
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