Predicted to enable several functions, including 7SK snRNA binding activity; P-TEFb complex binding activity; and cyclin-dependent protein serine/threonine kinase inhibitor activity. Acts upstream of or within heart development and negative regulation of DNA-templated transcription. Located in nucleus. Is expressed in several structures, including branchial arch; embryo mesenchyme; heart and pericardium; hindgut dorsal mesentery; and sensory organ. Orthologous to human HEXIM1 (HEXIM P-TEFb complex subunit 1).
MGI Description
PHENOTYPE: Mice homozygous for a gene trapped allele exhibit prenatal lethalilty associated with dilated cardiomyopathy. [provided by MGI curators]