Version: 8.0.0
Date: Tue Jan 28 2025
Gabbr2
Mus musculusMGI:2386030
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Gabbr2

Species
Mus musculus
Symbol
Gabbr2
Name
gamma-aminobutyric acid type B receptor subunit 2
Synonyms
  • G protein-coupled receptor 51
  • Gababr2
Biotype
protein coding gene
Automated Description
Predicted to enable G protein-coupled GABA receptor activity and protein heterodimerization activity. Predicted to be involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; gamma-aminobutyric acid signaling pathway; and neuron-glial cell signaling. Located in cytoplasm and neuron projection. Is expressed in brain; eye; and liver. Human ortholog(s) of this gene implicated in alcohol use disorder; developmental and epileptic encephalopathy 59; and nicotine dependence. Orthologous to human GABBR2 (gamma-aminobutyric acid type B receptor subunit 2).
MGI Description
PHENOTYPE: Homozygous mutation of this gene results in clonic seizures, hyperactivity, hyperalgesia in response to thermal or mechanical stimuli, increased anxiety, and decreased depression-related behavior. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10519
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
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    Variant type
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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        Models

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          Sequence Feature Viewer

          Genome location
          Assembly version
          GRCm39
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Gabbr2 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
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            Genetic Interactions

            Gabbr2 role
            Gabbr2 genetic perturbation
            Interactor gene
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            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
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