Version: 8.0.0
Date: Tue Jan 28 2025
Ppp1r9a
Mus musculusMGI:2442401
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Ppp1r9a

Species
Mus musculus
Symbol
Ppp1r9a
Name
protein phosphatase 1, regulatory subunit 9A
Synonyms
  • 2810430P21Rik
  • 4930518N04Rik
Biotype
protein coding gene
Automated Description
Predicted to enable several functions, including actin filament binding activity; enzyme binding activity; and transmembrane transporter binding activity. Involved in modulation of chemical synaptic transmission. Acts upstream of or within actin filament organization and calcium-mediated signaling. Located in cortical actin cytoskeleton; dendritic spine; and filopodium. Is expressed in several structures, including brain; extraembryonic component; genitourinary system; hemolymphoid system gland; and skeletal muscle. Orthologous to human PPP1R9A (protein phosphatase 1 regulatory subunit 9A).
MGI Description
PHENOTYPE: Mice homozygous for a knock-out allele exhibit defects in dopamine-mediated neuromodulation, deficient long-term potentiation at corticostriatal synapses, increased spontaneous excitatory post-synaptic current frequency, and enhanced locomotor activationin response to cocaine treatment. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR16154
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
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          Sequence Feature Viewer

          Genome location
          Assembly version
          GRCm39
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Ppp1r9a molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            Ppp1r9a role
            Ppp1r9a genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
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