Predicted to enable GTPase activator activity. Predicted to be involved in actin filament organization; negative regulation of small GTPase mediated signal transduction; and phagocytosis, engulfment. Predicted to be active in phagocytic cup. Is expressed in brain; cerebral cortex ventricular layer; pharyngo-tympanic tube; and vibrissa. Orthologous to human ARHGAP25 (Rho GTPase activating protein 25).
MGI Description
PHENOTYPE: Mice homozygous for a knock-out allele exhibit altered leukocyte transendothelial migration. [provided by MGI curators]