Version: 8.0.0
Date: Tue Jan 28 2025
Cfap69
Mus musculusMGI:2443778
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Cfap69

Species
Mus musculus
Symbol
Cfap69
Name
cilia and flagella associated protein 69
Synonyms
  • A330021E22Rik
  • AI427898
Biotype
protein coding gene
Automated Description
Involved in several processes, including positive regulation of fertilization; positive regulation of flagellated sperm motility; and response to odorant. Acts upstream of or within sperm axoneme assembly. Located in non-motile cilium. Is expressed in several structures, including brain; genitourinary system; gut gland; nasal cavity epithelium; and spinal cord ventricular layer. Used to study spermatogenic failure 24. Human ortholog(s) of this gene implicated in spermatogenic failure 24. Orthologous to human CFAP69 (cilia and flagella associated protein 69).
MGI Description
PHENOTYPE: Homozygous loss-of-function mutations in this gene result in male sterility associated with severe asthenoteratospermia and multiple morphological abnormalities of the sperm flagella. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR14716
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
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    Disease
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

          Model name
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          Associated Human Diseases
          Associated Phenotypes
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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCm39
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            5.63M5.64M5.65M5.66M5.67M5.68M5.69M5.70M5.71M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Cfap69 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
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              Genetic Interactions

              Cfap69 role
              Cfap69 genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
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              Phenotype or trait
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