Version: 8.0.0
Date: Tue Jan 28 2025
Nr1d1
Mus musculusMGI:2444210
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Nr1d1

Species
Mus musculus
Symbol
Nr1d1
Name
nuclear receptor subfamily 1, group D, member 1
Synonyms
  • A530070C09Rik
  • expressed sequence R75201
Biotype
protein coding gene
Automated Description
Enables DNA-binding transcription factor activity and E-box binding activity. Involved in several processes, including cellular response to cytokine stimulus; negative regulation of neuroinflammatory response; and regulation of biosynthetic process. Acts upstream of or within circadian rhythm and regulation of DNA-templated transcription. Located in cytoplasm; dendritic spine; and nucleus. Is expressed in several structures, including alimentary system; connective tissue; genitourinary system; nervous system; and retina. Human ortholog(s) of this gene implicated in brain small vessel disease. Orthologous to human NR1D1 (nuclear receptor subfamily 1 group D member 1).
MGI Description
PHENOTYPE: Homozygotes for targeted null mutations exhibit altered circadian behavior and temperature regulation with mild alterations in cytoarchitecture of the cerebellum. Litter size is reduced by half in mutant females. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24082
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          GRCm39
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Nr1d1 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            Nr1d1 role
            Nr1d1 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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