Version: 8.0.0
Date: Tue Jan 28 2025
Slc41a1
Mus musculusMGI:2444823
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Slc41a1

Species
Mus musculus
Symbol
Slc41a1
Name
solute carrier family 41, member 1
Synonyms
  • AI573938
  • B230315F01Rik
Biotype
protein coding gene
Automated Description
Enables inorganic cation transmembrane transporter activity. Involved in cellular response to magnesium ion and magnesium ion transmembrane transport. Predicted to be located in basolateral plasma membrane. Predicted to be part of protein-containing complex. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; mesenteric adipose tissue; and respiratory system. Human ortholog(s) of this gene implicated in nephronophthisis. Orthologous to human SLC41A1 (solute carrier family 41 member 1).
MGI Description
PHENOTYPE: Homozygous null mice exhibit partial rescue of the negative effects of magnesium starvation on Krebs cycle enzyme activity in cardiac mitochondria and increased electron transport chain complex I, III, IV, and V activities but decreased complex II activity irrespective of the type of magnesium diet. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR16228
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
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    Variant type
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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        Models

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          Sequence Feature Viewer

          Genome location
          Assembly version
          GRCm39
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Slc41a1 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
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            Genetic Interactions

            Slc41a1 role
            Slc41a1 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
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            Phenotype or trait
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