Species

Mus musculus

Symbol

Cpt1c

Name

carnitine palmitoyltransferase 1c

Synonyms

9630004I06Rik
CPT I-C

Biotype

protein coding gene

Automated Description

Enables palmitoyl-(protein) hydrolase activity. Involved in regulation of postsynaptic membrane neurotransmitter receptor levels. Located in axon; dendrite; and endoplasmic reticulum. Part of AMPA glutamate receptor complex. Is active in endoplasmic reticulum membrane; glutamatergic synapse; and postsynapse. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 73. Orthologous to human CPT1C (carnitine palmitoyltransferase 1C).

MGI Description

PHENOTYPE: Targeted mutations in this gene result in reduced body weight, increases in circulating fatty acid levels and mild insulin resistance. Mice homozygous for a different targeted knock-out exhibit reduced ceramide levels, impaired dendritic spine maturationand impaired spatial learning. [provided by MGI curators]

Cross References

Additional Information

Literature

Orthology

Gene tree: PANTHER:PTHR22589

Stringency:StringentModerateNo filter

Additional filters to further constrain the results:

Best Score OnlyBest Reverse Score Only

Count:Species:Methods:

Species	Gene symbol	Count	Best	Best reverse	Method Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiens	CPT1C	10 of 10	Yes	Yes	☑☑☑☑☑☑☑☑☑☑
Rattus norvegicus	Cpt1c	9 of 9	Yes	Yes	☑ ☑☑☑☑☑☑☑☑
Danio rerio	cpt1a2b	2 of 10	Yes	Yes	☑ ☐☐☐☐☐☑☐☐ ☐
Drosophila melanogaster	whd	8 of 9	Yes	No	☑ ☑☑☐☑☑☑☑☑
Caenorhabditis elegans	cpt-1	9 of 9	Yes	Yes	☑ ☑☑☑☑☑☑☑☑

Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse

Paralogy

Gene symbol	Rank	Alignment Length (aa)	Similarity %	Identity %	Method Count	Method Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
Cpt1a	1	774	70	53	7 of 9	☑☐☑☐☑☑☑☑☑
Cpt1b	2	773	67	51	7 of 9	☑☐☑☐☑☑☑☑☑
Crat	3	687	49	28	3 of 9	☑☐☐☐☐☐☑☑☐
Chat	4	667	45	30	3 of 9	☑☐☐☐☐☐☑☑☐
Cpt2	5	692	41	28	3 of 9	☑☐☐☐☐☐☑☑☐
Crot	6	642	45	28	3 of 9	☑☐☐☐☐☐☑☑☐

Function - GO Annotations

No function available for that gene

Pathways

No data available

Phenotypes

Primary Sources

MGI

Other Sources

Phenotype Term

Annotation details

References

abnormal dendritic spine morphology

View

PMID:22539351

abnormal lipid level

View

PMID:22539351

abnormal spatial learning

View

PMID:22539351

abnormal uterus morphology

View

MGI:5576271

decreased body weight

View

PMID:16651524

decreased bone mineral content

View

MGI:5576271

decreased brain weight

View

MGI:5576271

decreased food intake

View

PMID:16651524

decreased skeletal muscle cell glucose uptake

View

PMID:19224198

enhanced gluconeogenesis

View

PMID:19224198

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Disease Associations

	all annotations		all disease by infectious agent	bacterial infectious disease	fungal infectious disease	parasitic infectious disease	viral infectious disease		all disease of anatomical entity	cardiovascular system disease	central nervous system disease	endocrine system disease	gastrointestinal system disease	hematopoietic system disease	immune system disease	integumentary system disease	musculoskeletal system disease	peripheral nervous system disease	reproductive system disease	respiratory system disease	sensory system disease	thoracic disease	urinary system disease		all disease of cellular proliferation	benign neoplasm	cancer	pre-malignant neoplasm		all genetic disease	chromosomal disease	monogenic disease	polygenic disease		all other disease	disease of mental health	disease of metabolism	physical disorder	syndrome
Cpt1c (Mmu)

Cell color indicative of annotation volume

No data available

Alleles and Variants

No mapped variant information available

Allele/Variant Symbol	Allele Synonyms	Category	Variant
Cpt1c^{tm1a(EUCOMM)Wtsi}		allele
Cpt1c^tm1Fghe		allele		Yes
Cpt1c^Gt(XL823)Byg	Cpt1c^gt	allele
Cpt1c^tm1Dhwu		allele		Yes
Cpt1c^{tm1b(EUCOMM)Wtsi}		allele		Yes
Cpt1c^em2Cya	Cpt1c^em1flox	allele
Cpt1c^tm1Mdln		allele		Yes
NC_000073.7:g.44608049C>A		variant	rs224337327 SNP non coding transcript exon variant
NC_000073.7:g.44608234A>G		variant	rs251744995 SNP intron variant
NC_000073.7:g.44621818G>T		variant	rs37701960 SNP intron variant

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View detailed Alleles/Variants information

Download all Alleles/Variants for all genes of the species

Transgenic Alleles

No data available

Models

Model name	Associated Phenotypes	Source
Cpt1c^Gt(XL823)Byg/Cpt1c⁺ Nf1^tm1Tyj/Nf1⁺ Trp53^tm1Tyj/Trp53⁺ [background:] involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6	decreased metastatic potential decreased sarcoma incidence	MGI
Cpt1c^{tm1b(EUCOMM)Wtsi}/Cpt1c^{tm1b(EUCOMM)Wtsi} [background:] C57BL/6N-Cpt1c^{tm1b(EUCOMM)Wtsi}/Ucd	abnormal uterus morphology decreased bone mineral content	MGI
Cpt1c^tm1Dhwu/Cpt1c^tm1Dhwu [background:] involves: 129 * C57BL/6J	decreased skeletal muscle cell glucose uptake enhanced gluconeogenesis	MGI
Cpt1c^tm1Fghe/Cpt1c^tm1Fghe [background:] B6.129S-Cpt1c^tm1Fghe	abnormal dendritic spine morphology abnormal lipid level	MGI
Cpt1c^tm1Mdln/Cpt1c^tm1Mdln [background:] involves: C57BL/6	decreased body weight decreased food intake	MGI

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Sequence Feature Viewer

Genome location

Chr7:44608796...44624275 - (15.48 kb)

Assembly version

GRCm39

Viewer Help

Sequence Details

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Expression

Primary Sources

Other Sources

	all annotations		all anatomical structures	alimentary part of gastrointestinal system	chemosensory system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mechanosensory system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	vestibulo-auditory system	visual system	endoderm	ectoderm	mesoderm	mesenchyme	adipose tissue	appendage	entire extraembryonic component	imaginal precursor	pharyngeal arch	other		all stages	embryo stage	post embryonic, pre-adult	post-juvenile adult stage		all cellular components	extracellular region	plasma membrane	synapse	cell junction	cell projection	cytoplasmic vesicle	endosome	vacuole	golgi apparatus	endoplasmic reticulum	cytosol	mitochondrion	nucleus	chromosome	cytoskeleton	protein-containing complex	other locations
Cpt1c (Mmu)

Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

4 interactor genes based on 4 annotations

Cpt1c molecule type	Interactor gene	Interactor species	Interactor molecule type	Detection methods	Source	Reference
protein	Cfd	Mus musculus	protein	affinity chromatography technology	biogrid:2901703	PMID:30550785
protein	Fndc5	Mus musculus	protein	affinity chromatography technology	biogrid:2902199	PMID:30550785
protein	Gria1	Mus musculus	protein	proximity labelling technology	biogrid:3498748	PMID:36417873
protein	Gria2	Mus musculus	protein	proximity labelling technology	biogrid:3498789	PMID:36417873

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Genetic Interactions

No data available