Acts upstream of or within several processes, including BMP signaling pathway; cellular response to leukemia inhibitory factor; and positive regulation of osteoblast differentiation. Is expressed in several structures, including central nervous system; optic cup; retina; trigeminal nerve; and upper jaw incisor. Orthologous to human MIR210 (microRNA 210).
MGI Description
PHENOTYPE: Mice homozygous for one targeted knock-out allele exhibit increased anti-nuclear antigen antibody level and decreased germinal center B cell number. Homozygous KO also leads to a male-specific decrease in nephron number. [provided by MGI curators]