Version: 8.0.0
Date: Tue Jan 28 2025
Dagla
Mus musculusMGI:2677061
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Dagla

Species
Mus musculus
Symbol
Dagla
Name
diacylglycerol lipase, alpha
Synonyms
  • neural stem cell-derived dendrite regulator
  • Nsddr
Biotype
protein coding gene
Automated Description
Enables monoacylglycerol lipase activity. Involved in arachidonate metabolic process; regulation of neuroinflammatory response; and retrograde trans-synaptic signaling by endocannabinoid. Acts upstream of or within cannabinoid biosynthetic process; monoacylglycerol biosynthetic process; and neuroblast proliferation. Located in dendritic spine membrane and varicosity. Is active in postsynaptic membrane. Is expressed in brain and olfactory epithelium. Human ortholog(s) of this gene implicated in lung cancer. Orthologous to human DAGLA (diacylglycerol lipase alpha).
MGI Description
PHENOTYPE: Mice homozygous for null mutations have decreased body weight, adult neuronal proliferation, and nervous system endocannaboid levels and abnormal inhibitory postsynaptic currents. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR45792
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCm39
            Viewer Help
            10.23M10.24M10.25M10.26M10.27M10.28M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Dagla molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
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              Genetic Interactions

              Dagla role
              Dagla genetic perturbation
              Interactor gene
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              Interactor role
              Interactor genetic perturbation
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              Phenotype or trait
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