Version: 8.0.0
Date: Tue Jan 28 2025
Klhl17
Mus musculusMGI:2678948
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Klhl17

Species
Mus musculus
Symbol
Klhl17
Name
kelch-like 17
Synonyms
  • actinfilin
  • AL022703
Biotype
protein coding gene
Automated Description
Predicted to enable POZ domain binding activity; actin filament binding activity; and ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in actin cytoskeleton organization; proteasome-mediated ubiquitin-dependent protein catabolic process; and regulation protein catabolic process at postsynapse. Predicted to be located in actin cytoskeleton; dendrite cytoplasm; and neuronal cell body. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm; glutamatergic synapse; and postsynapse. Orthologous to human KLHL17 (kelch like family member 17).
MGI Description
PHENOTYPE: Mice homozygous and heterozygous for a null allele exhibit reduced width of dendritic spine heads in neurons. Heterozygotes also show slightly increased mEPSC amplitude, hyperactivity and increased rearing, and reduced social interaction. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24412
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
    Evidence
    Source
    Based On
    References
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
      Has Disease Annotations
      Has Phenotype Annotations
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        Download all Alleles/Variants for all genes of the species

        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
        Has Disease Annotations
        Has Phenotype Annotations
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
          Modifier
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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCm39
            Viewer Help
            156.3140M156.3145M156.3150M156.3155M156.3160M156.3165M156.3170M156.3175M156.3180M156.3185M156.3190M

            Sequence Details

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            Expression

            Primary Sources
            None
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Klhl17 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
            Reference
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              Genetic Interactions

              Klhl17 role
              Klhl17 genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
              Source
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