Gene

Hcrtr2

Species
Mus musculus
Symbol
Hcrtr2
Name
hypocretin (orexin) receptor 2
Synonyms
  • mOX2aR
  • mOX2bR
Biotype
protein coding gene
Automated Description
Enables orexin receptor activity. Involved in locomotion. Acts upstream of or within phospholipase C-activating G protein-coupled receptor signaling pathway. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; genitourinary system; liver; lung; and spleen. Used to study narcolepsy. Orthologous to human HCRTR2 (hypocretin receptor 2).
MGI Description
PHENOTYPE: Mice bearing targeted mutations in this gene exhibit fragmentation of sleep/wake states with similarity to narcolepsy and rare or very rare episodes of cataplexy. In addition, mice homozygous for a funtionally null allele display enhanced depression-likebehavior. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24241
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
abnormal depression-related behavior
abnormal muscle tone
abnormal neuron physiology
abnormal non-rapid eye movement sleep pattern
abnormal paradoxical sleep pattern
abnormal sleep pattern
fragmentation of sleep/wake states
narcolepsy
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Transgenic Alleles

No data available

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
76.14M76.15M76.16M76.17M76.18M76.19M76.20M76.21M76.22M76.23M

Sequence Details

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Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions