Acts upstream of or within labyrinthine layer development and myoblast fusion. Predicted to be located in plasma membrane. Is expressed in several structures, including extraembryonic component; ganglia; heart ventricle; musculoskeletal system; and placenta. Orthologous to human ERVFRD-1 (endogenous retrovirus group FRD member 1, envelope).
MGI Description
PHENOTYPE: Mice homozygous for a knock-out allele exhibit lethality between E11.5 and E14.5 associated with defective placental layrinth formation, impaired placental transport, and increased trophoblast cells. [provided by MGI curators]