Version: 8.0.0
Date: Tue Jan 28 2025
Oxgr1
Mus musculusMGI:2685145
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Oxgr1

Species
Mus musculus
Symbol
Oxgr1
Name
oxoglutarate (alpha-ketoglutarate) receptor 1
Synonyms
  • Cysltr3
  • G protein-coupled receptor 80
Biotype
protein coding gene
Automated Description
Predicted to enable AMP binding activity; G protein-coupled adenosine receptor activity; and purine nucleoside binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within adenylate cyclase-modulating G protein-coupled receptor signaling pathway. Predicted to be active in plasma membrane. Is expressed in epididymis; metanephros; neural retina; and retina. Human ortholog(s) of this gene implicated in calcium oxalate nephrolithiasis. Orthologous to human OXGR1 (oxoglutarate receptor 1).
MGI Description
PHENOTYPE: Mice homozygous for a knock-out allele exhibit reduced leukotriene E4 ligand (LTE4)-induced ear edema at low and intermediate doses and abnormal acid-base balance. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24231
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensOXGR110 of 10YesYes☑☑☑☑☑☑☑☑☑☑  
Rattus norvegicusOxgr19 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Danio reriooxgr1a.210 of 10YesYes☑ ☑☑☑☑☑☑☑☑ ☑
Danio reriooxgr1a.310 of 10YesYes☑ ☑☑☑☑☑☑☑☑ ☑
Danio reriooxgr1a.110 of 10YesYes☑ ☑☑☑☑☑☑☑☑ ☑
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
P2ry1132057383 of 9☑☐☐☐☐☐☑☑☐ 
P2ry4231955323 of 9☑☐☐☐☐☐☑☑☐ 
P2ry2331255343 of 9☑☐☐☐☐☐☑☑☐ 
Cysltr2431952342 of 9☑☐☐☐☐☐☐☑☐ 
Sucnr1528855333 of 9☑☐☐☐☐☐☑☑☐ 
P2ry6628851353 of 9☑☐☐☐☐☐☑☑☐ 
Hcar2732046282 of 9☑☐☐☐☐☐☐☑☐ 
Ffar3829049282 of 9☑☐☐☐☐☐☐☑☐ 
Gpr31b930647272 of 9☑☐☐☐☐☐☐☑☐ 
Hcar11030647252 of 9☑☐☐☐☐☐☐☑☐ 
Ffar21131145252 of 9☑☐☐☐☐☐☐☑☐ 
Gpr821231545222 of 9☑☐☐☐☐☐☐☑☐ 
Ffar11325639262 of 9☑☐☐☐☐☐☐☑☐ 

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
abnormal immune system physiology
decreased circulating chloride level
decreased urine pH
increased circulating bicarbonate level
Showing 1 - 4 of 4 rows
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume
Species
Gene
Association
Disease Qualifier
Disease
Evidence
Source
Based On
References
No records match query. Try removing filters.
Showing 0 - 0 of 0 rows
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    Alleles and Variants

    Genome location
    Assembly version
    GRCm39
    Viewer Help
    Data currently unavailable; sequence viewer under construction
    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
    Oxgr1em1Smocallele
    Oxgr1em1Cya
    • Oxgr1em1
    		allele
    Oxgr1tm1.1(KOMP)Vlcgallele
    Oxgr1Gt(OST404323)Lexallele
    Oxgr1tm1(KOMP)Vlcg
    • Oxgr1tm1Vlcg
    		allele
    		Yes
    NC_000080.7:g.120258864C>Tvariant
    SNP
    • 3 prime UTR variant
    NC_000080.7:g.120258925G>Avariant
    SNP
    • 3 prime UTR variant
    NC_000080.7:g.120258927C>Tvariant
    SNP
    • 3 prime UTR variant
    NC_000080.7:g.120277231C>Avariant
    SNP
    • intron variant
    NC_000080.7:g.120263480A>Tvariant
    SNP
    • intron variant
    Showing 1 - 10 of 688 rows
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    View detailed Alleles/Variants information
    Download all Alleles/Variants for all genes of the species

    Transgenic Alleles

    No data available

    Models

    Model name
    Experimental condition
    Associated Human Diseases
    Associated Phenotypes
    Modifier
    Source
    Cysltr1tm1Ykn/Cysltr1tm1Ykn Cysltr2tm1Ykn/Cysltr2tm1Ykn Oxgr1tm1(KOMP)Vlcg/Oxgr1tm1(KOMP)Vlcg [background:] involves: BALB/c * C57BL/6 * C57BL/6NTac
    • abnormal immune system physiology
    		MGI
    Oxgr1tm1(KOMP)Vlcg/Oxgr1tm1(KOMP)Vlcg [background:] involves: BALB/c * C57BL/6NTac
    • abnormal immune system physiology
    		MGI
    Oxgr1tm1(KOMP)Vlcg/Oxgr1tm1(KOMP)Vlcg [background:] involves: C57BL/6J * C57BL/6NTac
    • decreased circulating chloride level
    • decreased urine pH
    		MGI
    Showing 1 - 3 of 3 rows
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    Sequence Feature Viewer

    Genome location
    Assembly version
    GRCm39
    Viewer Help
    Data currently unavailable; sequence viewer under construction

    Sequence Details

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    Expression

    Primary Sources
    Other Sources
    Must provide at least one subject
    Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

    Molecular Interactions

    No data available

    Genetic Interactions

    No data available