leucine-rich repeat, immunoglobulin-like and transmembrane domains 3
Synonyms
gene model 421, (NCBI)
Gm421
Biotype
protein coding gene
Automated Description
Acts upstream of or within several processes, including synapse assembly involved in innervation; synaptic signaling; and visual perception. Is active in cell tip and dendrite. Used to study congenital stationary night blindness 1F. Human ortholog(s) of this gene implicated in congenital stationary night blindness 1F. Orthologous to human LRIT3 (leucine rich repeat, Ig-like and transmembrane domains 3).
MGI Description
PHENOTYPE: Mice homozygous for a targeted allele show a selective absence of the ERG b-wave with a
normal a-wave component under scotopic conditions, as well as variable ERG responses with larger a-wave amplitudes, shorter b-wave amplitudes, and longer implicit times of both waves under photopic conditions.
[provided by MGI curators]