Gene

Lrit3

Species
Mus musculus
Symbol
Lrit3
Name
leucine-rich repeat, immunoglobulin-like and transmembrane domains 3
Synonyms
  • gene model 421, (NCBI)
  • Gm421
Biotype
protein coding gene
Automated Description
Acts upstream of or within several processes, including synapse assembly involved in innervation; synaptic signaling; and visual perception. Is active in cell tip and dendrite. Used to study congenital stationary night blindness 1F. Human ortholog(s) of this gene implicated in congenital stationary night blindness 1F. Orthologous to human LRIT3 (leucine rich repeat, Ig-like and transmembrane domains 3).
MGI Description
PHENOTYPE: Mice homozygous for a targeted allele show a selective absence of the ERG b-wave with a normal a-wave component under scotopic conditions, as well as variable ERG responses with larger a-wave amplitudes, shorter b-wave amplitudes, and longer implicit times of both waves under photopic conditions. [provided by MGI curators]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR45842
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCm39
Viewer Help
129.582M129.584M129.586M129.588M129.590M129.592M129.594M129.596M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions